Search results for " Gene expression data"

showing 2 items of 2 documents

An Extension of the DgLARS Method to High-Dimensional Relative Risk Regression Models

2020

In recent years, clinical studies, where patients are routinely screened for many genomic features, are becoming more common. The general aim of such studies is to find genomic signatures useful for treatment decisions and the development of new treatments. However, genomic data are typically noisy and high dimensional, not rarely outstripping the number of patients included in the study. For this reason, sparse estimators are usually used in the study of high-dimensional survival data. In this paper, we propose an extension of the differential geometric least angle regression method to high-dimensional relative risk regression models.

Clustering high-dimensional dataComputer sciencedgLARS Gene expression data High-dimensional data Relative risk regression models Sparsity · Survival analysisLeast-angle regressionRelative riskStatisticsEstimatorRegression analysisExtension (predicate logic)High dimensionalSettore SECS-S/01 - StatisticaSurvival analysis
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Regularized Regression Incorporating Network Information: Simultaneous Estimation of Covariate Coefficients and Connection Signs

2014

We develop an algorithm that incorporates network information into regression settings. It simultaneously estimates the covariate coefficients and the signs of the network connections (i.e. whether the connections are of an activating or of a repressing type). For the coefficient estimation steps an additional penalty is set on top of the lasso penalty, similarly to Li and Li (2008). We develop a fast implementation for the new method based on coordinate descent. Furthermore, we show how the new methods can be applied to time-to-event data. The new method yields good results in simulation studies concerning sensitivity and specificity of non-zero covariate coefficients, estimation of networ…

Clustering high-dimensional databusiness.industryjel:C41jel:C13Machine learningcomputer.software_genreRegressionhigh-dimensional data gene expression data pathway information penalized regressionConnection (mathematics)Set (abstract data type)Lasso (statistics)CovariateArtificial intelligenceSensitivity (control systems)businessCoordinate descentAlgorithmcomputerMathematics
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